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Journal publications
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Applications of Cytotoxicity Assays and Pre-lethal Mechanistic Assays for Assessment of Human Hepatotoxicity Potential.
Xu, J.J.. Diaz, D., O’Brien, P.J.
Chemical and Biological Interactions, 150, 1:115-28

Drug-drug interaction of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338
Furuta S., Kamada E., Omata T., Sugimoto T., Kawabata Y., Yonezawa K., Wu X.C. and Kurimoto T.
European Journal of Pharmacology , 497: 223-231

Molecular similarity and property similarity
Barbosa F., Horvath D.
Current topics in Medicinal Chemistry, 4(6):589-600

Strengths and Limitations of Pharmacophore-Based Virtual Screening in “Cheminformatics in Drug Discovery"
Horvath, D., Mao, B., Gozalbes, R., Barbosa, F., Rogalski, S.L.
Oprea, T.I. (ed.),

Affinity of cyamemazine, an anxiolytic antipsychotoc drug, for human recombinant dopamine vs. Serotonin receptors subtypes
Hameg A., Bayle F., Nuss P., Dupuis P., Garay RP., Dib M.
Biochem Pharmacol., 65(3):435-40

Antinociceptive activity of the N-Methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide Hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain
Villetti G., Bergamaschi M., Bassani F., Bolzoni P.T.,Maiorino M., Pietra C., Rondelli I., Chamiot-Clerc P., Simonatto M. and Barbieri M.
Journal Pharmacol. Exp. Ther. , 306: 804–814

Differential effects of sulphonylureas on the vasodilatory response evoked by KATP channel openers.
Ravel D., Levens N., Feletou M., Neliat G., Auclair J. and Bouskela E.
Fundam. Clin. Pharmacol., 17 : 61-69.

Fluorinated Ketene Dithioacetals. Part 10. Synthesis of new perfluorinated (2H)-pyridazin-3-ones and 3-(Alkyl- or Arylamino) substitued pyridazines
Brulé C., Bouillon J-Ph., Nicolai E., Portella Ch. (2003)
Synthesis, Journal of Synthetic Organic Chemistry , 3: 436-442

Neighborhood Behavior. Fuzzy Molecular Descriptors and their Influence on the Relationship between Structural Similarity and Property Similarity
Horvath, D., Mao B.
QSAR Comb. Sci., 22(5): 498-509

Neighborhood behavior of in silico structural spaces with respect to in vitro activity spaces - A Benchmark for neighborhood behavior assessment of different in silico similarity metrics.
Horvath, D., Jeandenans, C. (2003)
J. Chem. Inf. Comp. Sci,, 43: 691-698

Neighborhood behavior of in silico structural spaces with respect to in vitro activity spaces - A novel understanding of the molecular similarity principle in the context of multiple receptor binding profiles.
Horvath D., Jeandenans C. (2003)
J. Chem. Inf. Comp. Sci., 43: 680-690

Predicting ADME properties and side effects: The BioPrint approach.
Krejsa C. M., Horvath D., Rogalski S. L., Penzotti J. E., Mao B., Barbosa F., Migeon J. C.
Curr. Opin. Drug. Discov. Devel., 6(4): 471-480

The in vitro, ex vivo and in vivo demonstration of slimming liposomes lipolytic effect : an unexpected a2-adrenergic antagonism.
Tholon L., Neliat G., Chesne C., Saboureau D., Perrier E. and Bra Nka J.-E.
J. Cosmet. Sci. , 53 : 209-218.

ComPharm - Automated comparative analysis of pharmacophoric patterns and derived QSAR approaches, novel tools in High throughput Drug discovery. A proof of concept study applied to farnesyl protein transferase inhibitor design
Horvath, D. (2001)
“QSPR / QSAR Studies by Molecular Descriptors”, Diudea, M., Editor, Nova Science Publishers, Inc., New York, 395-439

From hit to lead. Analyzing structure-profile relationships
Poulain R., Horvath D., Bonnet B., Eckoff C., Chapelain B., Bodinier M-C., Déprez B. (2001)
J. Med. Chem. , 44 (21): 3391-3401

From hit to lead. Combining two complementary methods for focused library design application to µ opiate ligands
Poulain R., Horvath D., Bonnet B., Eckoff C., Chapelain B., Bodinier M-C., Déprez B. (2001)
J. Med. Chem. , 44 (21): 3378-3390

Functional modulation of gamma-aminobutyric acidA receptors by etifoxine and allopregnanolone in rodents.
Verleye M., Schlichter R., Neliat G., Pansart Y. and Gillardin J.M.
Neurosci. Lett. , 301 : 191-194.

High Throughput conformational sampling & fuzzy similarity metrics: A novel approach to similarity searching and focused combinatorial library design and its role in the Drug discovery laboratory,
Horvath, D. (2001)
“Combinatorial Library Design and Evaluation: Principles, Software Tools and Applications”, Ghose, A. & Viswanadhan,V. Eds., Marcel Dekker, Inc., New York, 429-472

Recursive Partitioning analysis of µ-opiate receptor high throughput screening results
Horvath, D
SAR QSAR Environ. Res. , 12(1-2):181-212

Genistein and daidzein modulate in vitro rat uterine contractile activity.
Picherit C., Dalle M., Neliat G., Lebecque P., Davicco M.J., Barlet J.P. and Coxam V.
J. Steroid Biochem. Mol. Biol. , 75 : 201-208.

High Troughput Drug Profiling
Entzeroth M., Chapelain B., Guilbert J., Hamon V.
JALA, 5 (4):69-71

Reactivity prediction models applied to the selection of novel candidate building blocks for High throughput organic synthesis of combinatorial libraries
Braban M., Pop, I., Willard X, Horvath, D. (1999)
J. Chem. Inf. Comp. Sci., 39: 1119-1127

Receptor binding profile of Otilonium bromide.
Evangelista S., Giachetti A., Chapelain B., Neliat G. and Maggi, C.A.
Pharmacol. Res. , 38: 111-117

A virtual screening approach applied to the search of trypanothione reductase inhibitors
Horvath, D. (1997)
J. Med. Chem. , 15: 2412-2423

Biochemical and pharmacological activities of SR 144190, a new potent non-peptide tachykinin NK2 receptor antagonist.
Emonds-Alt X., Advenier C., Cognon C., Croci T., Daoui S., Ducoux J.P., Landi M., Naline E., Neliat G., Poncelet M., Proietto V., Van Broeck D., Vilain P., Soubrié P., Le Fur G., Maffrand J.P. and Brelière J.C.
Neuropeptides , 31 : 449-458.

High throughput molecular modeling using fast 3D descriptors
Horvath, D., Deprez B., Tartar A. (1997)
Act. Chim. Ther. , 23: 55-67

Combinatorial chemistry: A rational approach to chemical diversity
Willard X., Pop I., Horvath, D., Baudelle R., Melnyk P., Deprez B., Tartar A. (1996)
Eur. J. Med. Chem. , 31: 87

Lack of effect of repeated administration of milnacipran, a double noradrenaline and serotonin reuptake inhibitor, on the b-adrenoceptor-linked adenylate cyclase system in the rat cerebral cortex.
Neliat G., Bodinier M.-C., Panconi E. and Briley M.
Neuropharmacol. , 35 : 589-593.

The naphtosultam derivative RP 62203 (fananserin) has a high affinity for the dopamine D4 receptor.
Heuillet E., Petitet F., Mignani S., Malleron J.-L., Lavayre J., Neliat G., Doble A. and Blanchard J.-C.
Eur. J. Pharmacol., 314 : 229-233.

Combinatorial chemistry: A rational access to molecular diversity
Melnyk P., Bourel L., Willard X., Pop I., Horvath, D., Deprez B., Tartar A. (1995-1996)
Act. Chim. Ther.,

SR 120819A, an orally-active and selective neuropeptide Y Y1 receptor antagonist.
Serradeil-Le Gal C., Valette G., Rouby P.-E., Pellet A., Oury-Donat F., Brossard G., Lespy L., Marty E., Neliat G., de Cointet P., Maffrand J.-P. and Le Fur G.
FEBS Lett. , 362 : 192-196.

SR 141716A, a potent and selective antagonist of the brain canabinoid receptor
Rinaldi-Carmona M., Barth F., Heaulme M., Shire D., Calandra B., Congy C., Martinez S., Maruani J., Neliat G., Caput D., Ferrara P., Soubrie P., Breliere J.P. and Le Fur G.
FEBS Lett., 350 : 240-244.

SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor.
Emonds-Alt X., Bichon D., Ducoux J.P., Heaulme M., Miloux B., Poncelet M., Proietto V., Van Broeck D., Vilain P., Neliat G., Soubrié P., Le Fur G. and Brelière J.C.
Life Sci. , 56 : 27-32.

Synthèse combinatoire
Bourel L., Willard X., Pop I., Baudelle R., Horvath D., Deprez B., MelnykP., Tartar A. (1995)
L'Actualité Chimique ,

Effects of an extract of Ginko biloba on the action potential and associated transmembrane ionic currents in mammalian cardiac myocytes : inhibition of isoproterenol-induced chloride current
Masson F., Néliat G., Drieu K., Defeudis F. and Jean T. (1994)
Drug Development Research , 32: 29-41

Effects of repeated treatment with an extract of Ginkgo biloba (EGb 761), Bilobalide and Ginkgolide B on the electrical activity of pancreatic ß cells of normal and alloxan-diabetic mice : an ex vivo study with intracellular microelectrodes
Vasseur M., Jean T., Defeudis F., and Drieu K. (1994)
Gen. Pharmacol. , 25: 31-46

Etude in vitro de l'effet anti-inflammatoire de la diosmine d'hémisynthèse dans un système de co-culture de cellules endothéliales veineuses et de granulocytes humains
Bodinier M.C., Ly S.M., Finet M. and Jean T. (1994)
Artères et veines , 13: 124-128

Mediators involved in inflammation: effects of Daflon 500 mg on their release.
Jean T. and Bodinier M.C. (1994)
Angiology, 45: 554-559

Up-regulation of [3H]-des-Arg10-kallidin binding to the bradykinin B1 receptor by interleukin-1ß in isolated smooth muscle cells: correlation with B1 agonist-induced PGI2 production
Galizzi J.P., Bodinier M.C., Chapelain B., Ly S.M., Coussy L., Giraud S., Néliat G. and Jean T. (1994)
Br. J. Pharmacol. , 113: 389-394

Different effects of interleukin-1 on reactivity of arterial vessels isolated from various vascular beds in the rabbit
Robert R., Chapelain B. and Neliat G. (1993)
Circ. Shock, 40: 139-143

In vitro and in vivo biological activities of SR 140333, a novel potent non-peptide tachykinin NK1 receptor antagonist.
Emonds-Alt X., Doutremepuich J.D., Heaulme M., Neliat G., Santucci V., Steinberg R., Vilain P., Bichon D., Ducoux J.P., Proietto V., Van Broeck D., Soubrié P., Le Fur G. and Brelière J.C (1993)
Eur. J. Pharmacol., 250: 403

Peripheral biological activity of SR 27897 : a new potent non-peptide antagonist of CCKA receptors
Gully D., Frehel D., Marcy C., Spinazze A., Lespy L., Neliat G., Maffrand J. P. and Le Fur G. (1993)
Eur. J .Pharmacol. , 232: 13-19

SR 48968, a neurokinin A (NK2) receptor antagonist
Emonds-Alt X., Advenier C., Croci T., Manara L., Neliat G., Poncelet M., Proietto V., Santucci V., Soubrié P., Van Broeck D., Vilain P., Le Fur G., and Brelière J. C. (1993)
Reg. Peptides, 43: 31-36

Study of anthiatherogenic properties of indapamide in a pharmacologic model
Lebrillant E., Roulet M. J., Robert R., Schiavi P., Guez D., and Jean T. (1993)
J. Cardiovasc. Pharmacol., 22: (sup. 6) S53-S56

A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor.
Emonds-Alt X., Vilain P., Goulaouic P., Proietto, V., Van Broeck D., Advenier C., Naline E., Neliat G., Le Fur G. and Brelière J.C. (1992)
Life Sci. (1992), 50: PL101-PL106

Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist
Rinaldi-Carmona M., Congy C., Santucci V.,Simiand J., Neliat G., Labeeuw G., Le Fur G., Soubrié P. and Brelière J. C. (1992)
J. Pharmacol. Exp. Ther. , 262: 759-768

Interleukin-1 impairs both vascular contraction and relaxation in rabbit isolated aorta.
Robert R., Chapelain B., Jean T., and Neliat G.
Biochem. Biophys. Res. Commun., (1992), 182: 733-739

Neurokinin A (NK2) receptor revisited with SR 48968, a potent non-peptide antagonist.
Advenier C., Rouissi N., Nguyen Q. T., Emonds-Alt X., Brelière J.C., Neliat G., Naline E., and Regoli D. (1992)
Biochem. Biophys. Res. Commun. , 184: 1418-1424

Characterization of ß-adrenoceptor subtypes and indications for two cell populations in isolated bovine mesenteric lymphatic vessels.
Mahé L., Chapelain B., Gargouil Y. M., and Neliat G. (1991)
Eur. J. Pharmacol., 199: 19-25

Role of the epithelium in the action of fenspiride on the isolated guinea-pig and rat trachea.
Chapelain B., Neliat G., Bodinier M. C., Jean T., Evrard Y., and Gargouil Y. M.
Eur. Respir. Rev., (1991), 2: 86-92


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