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| Journal publications |
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| Applications of Cytotoxicity Assays and Pre-lethal Mechanistic Assays for Assessment of Human Hepatotoxicity Potential. |
| Xu, J.J.. Diaz, D., O’Brien, P.J. |
| Chemical and Biological Interactions, 150, 1:115-28 |
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| Drug-drug interaction of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338 |
| Furuta S., Kamada E., Omata T., Sugimoto T., Kawabata Y., Yonezawa K., Wu X.C. and Kurimoto T. |
| European Journal of Pharmacology , 497: 223-231 |
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| Molecular similarity and property similarity |
| Barbosa F., Horvath D. |
| Current topics in Medicinal Chemistry, 4(6):589-600 |
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| Strengths and Limitations of Pharmacophore-Based Virtual Screening in “Cheminformatics in Drug Discovery" |
| Horvath, D., Mao, B., Gozalbes, R., Barbosa, F., Rogalski, S.L. |
| Oprea, T.I. (ed.), |
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| Affinity of cyamemazine, an anxiolytic antipsychotoc drug, for human recombinant dopamine vs. Serotonin receptors subtypes |
| Hameg A., Bayle F., Nuss P., Dupuis P., Garay RP., Dib M. |
| Biochem Pharmacol., 65(3):435-40 |
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| Antinociceptive activity of the N-Methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide Hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain |
| Villetti G., Bergamaschi M., Bassani F., Bolzoni P.T.,Maiorino M., Pietra C., Rondelli I., Chamiot-Clerc P., Simonatto M. and Barbieri M. |
| Journal Pharmacol. Exp. Ther. , 306: 804–814 |
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| Differential effects of sulphonylureas on the vasodilatory response evoked by KATP channel openers. |
| Ravel D., Levens N., Feletou M., Neliat G., Auclair J. and Bouskela E. |
| Fundam. Clin. Pharmacol., 17 : 61-69. |
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| Fluorinated Ketene Dithioacetals. Part 10. Synthesis of new perfluorinated (2H)-pyridazin-3-ones and 3-(Alkyl- or Arylamino) substitued pyridazines |
| Brulé C., Bouillon J-Ph., Nicolai E., Portella Ch. (2003) |
| Synthesis, Journal of Synthetic Organic Chemistry , 3: 436-442 |
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| Neighborhood Behavior. Fuzzy Molecular Descriptors and their Influence on the Relationship between Structural Similarity and Property Similarity |
| Horvath, D., Mao B. |
| QSAR Comb. Sci., 22(5): 498-509 |
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| Neighborhood behavior of in silico structural spaces with respect to in vitro activity spaces - A Benchmark for neighborhood behavior assessment of different in silico similarity metrics. |
| Horvath, D., Jeandenans, C. (2003) |
| J. Chem. Inf. Comp. Sci,, 43: 691-698 |
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| Neighborhood behavior of in silico structural spaces with respect to in vitro activity spaces - A novel understanding of the molecular similarity principle in the context of multiple receptor binding profiles. |
| Horvath D., Jeandenans C. (2003) |
| J. Chem. Inf. Comp. Sci., 43: 680-690 |
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| Predicting ADME properties and side effects: The BioPrint approach. |
| Krejsa C. M., Horvath D., Rogalski S. L., Penzotti J. E., Mao B., Barbosa F., Migeon J. C. |
| Curr. Opin. Drug. Discov. Devel., 6(4): 471-480 |
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| The in vitro, ex vivo and in vivo demonstration of slimming liposomes lipolytic effect : an unexpected a2-adrenergic antagonism. |
| Tholon L., Neliat G., Chesne C., Saboureau D., Perrier E. and Bra Nka J.-E. |
| J. Cosmet. Sci. , 53 : 209-218. |
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| ComPharm - Automated comparative analysis of pharmacophoric patterns and derived QSAR approaches, novel tools in High throughput Drug discovery. A proof of concept study applied to farnesyl protein transferase inhibitor design |
| Horvath, D. (2001) |
| “QSPR / QSAR Studies by Molecular Descriptors”, Diudea, M., Editor, Nova Science Publishers, Inc., New York, 395-439 |
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| From hit to lead. Analyzing structure-profile relationships |
| Poulain R., Horvath D., Bonnet B., Eckoff C., Chapelain B., Bodinier M-C., Déprez B. (2001) |
| J. Med. Chem. , 44 (21): 3391-3401 |
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| From hit to lead. Combining two complementary methods for focused library design application to µ opiate ligands |
| Poulain R., Horvath D., Bonnet B., Eckoff C., Chapelain B., Bodinier M-C., Déprez B. (2001) |
| J. Med. Chem. , 44 (21): 3378-3390 |
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| Functional modulation of gamma-aminobutyric acidA receptors by etifoxine and allopregnanolone in rodents. |
| Verleye M., Schlichter R., Neliat G., Pansart Y. and Gillardin J.M. |
| Neurosci. Lett. , 301 : 191-194. |
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| High Throughput conformational sampling & fuzzy similarity metrics: A novel approach to similarity searching and focused combinatorial library design and its role in the Drug discovery laboratory, |
| Horvath, D. (2001) |
| “Combinatorial Library Design and Evaluation: Principles, Software Tools and Applications”, Ghose, A. & Viswanadhan,V. Eds., Marcel Dekker, Inc., New York, 429-472 |
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| Recursive Partitioning analysis of µ-opiate receptor high throughput screening results |
| Horvath, D |
| SAR QSAR Environ. Res. , 12(1-2):181-212 |
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| Genistein and daidzein modulate in vitro rat uterine contractile activity. |
| Picherit C., Dalle M., Neliat G., Lebecque P., Davicco M.J., Barlet J.P. and Coxam V. |
| J. Steroid Biochem. Mol. Biol. , 75 : 201-208. |
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| High Troughput Drug Profiling |
| Entzeroth M., Chapelain B., Guilbert J., Hamon V. |
| JALA, 5 (4):69-71 |
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| Reactivity prediction models applied to the selection of novel candidate building blocks for High throughput organic synthesis of combinatorial libraries |
| Braban M., Pop, I., Willard X, Horvath, D. (1999) |
| J. Chem. Inf. Comp. Sci., 39: 1119-1127 |
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| Receptor binding profile of Otilonium bromide. |
| Evangelista S., Giachetti A., Chapelain B., Neliat G. and Maggi, C.A. |
| Pharmacol. Res. , 38: 111-117 |
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| A virtual screening approach applied to the search of trypanothione reductase inhibitors |
| Horvath, D. (1997) |
| J. Med. Chem. , 15: 2412-2423 |
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| Biochemical and pharmacological activities of SR 144190, a new potent non-peptide tachykinin NK2 receptor antagonist. |
| Emonds-Alt X., Advenier C., Cognon C., Croci T., Daoui S., Ducoux J.P., Landi M., Naline E., Neliat G., Poncelet M., Proietto V., Van Broeck D., Vilain P., Soubrié P., Le Fur G., Maffrand J.P. and Brelière J.C. |
| Neuropeptides , 31 : 449-458. |
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| High throughput molecular modeling using fast 3D descriptors |
| Horvath, D., Deprez B., Tartar A. (1997) |
| Act. Chim. Ther. , 23: 55-67 |
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| Combinatorial chemistry: A rational approach to chemical diversity |
| Willard X., Pop I., Horvath, D., Baudelle R., Melnyk P., Deprez B., Tartar A. (1996) |
| Eur. J. Med. Chem. , 31: 87 |
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| Lack of effect of repeated administration of milnacipran, a double noradrenaline and serotonin reuptake inhibitor, on the b-adrenoceptor-linked adenylate cyclase system in the rat cerebral cortex. |
| Neliat G., Bodinier M.-C., Panconi E. and Briley M. |
| Neuropharmacol. , 35 : 589-593. |
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| The naphtosultam derivative RP 62203 (fananserin) has a high affinity for the dopamine D4 receptor. |
| Heuillet E., Petitet F., Mignani S., Malleron J.-L., Lavayre J., Neliat G., Doble A. and Blanchard J.-C. |
| Eur. J. Pharmacol., 314 : 229-233. |
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| Combinatorial chemistry: A rational access to molecular diversity |
| Melnyk P., Bourel L., Willard X., Pop I., Horvath, D., Deprez B., Tartar A. (1995-1996) |
| Act. Chim. Ther., |
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| SR 120819A, an orally-active and selective neuropeptide Y Y1 receptor antagonist. |
| Serradeil-Le Gal C., Valette G., Rouby P.-E., Pellet A., Oury-Donat F., Brossard G., Lespy L., Marty E., Neliat G., de Cointet P., Maffrand J.-P. and Le Fur G. |
| FEBS Lett. , 362 : 192-196. |
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| SR 141716A, a potent and selective antagonist of the brain canabinoid receptor |
| Rinaldi-Carmona M., Barth F., Heaulme M., Shire D., Calandra B., Congy C., Martinez S., Maruani J., Neliat G., Caput D., Ferrara P., Soubrie P., Breliere J.P. and Le Fur G.
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| FEBS Lett., 350 : 240-244. |
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| SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor. |
| Emonds-Alt X., Bichon D., Ducoux J.P., Heaulme M., Miloux B., Poncelet M., Proietto V., Van Broeck D., Vilain P., Neliat G., Soubrié P., Le Fur G. and Brelière J.C. |
| Life Sci. , 56 : 27-32. |
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| Synthèse combinatoire |
| Bourel L., Willard X., Pop I., Baudelle R., Horvath D., Deprez B., MelnykP., Tartar A. (1995) |
| L'Actualité Chimique , |
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| Effects of an extract of Ginko biloba on the action potential and associated transmembrane ionic currents in mammalian cardiac myocytes : inhibition of isoproterenol-induced chloride current |
| Masson F., Néliat G., Drieu K., Defeudis F. and Jean T. (1994) |
| Drug Development Research , 32: 29-41 |
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| Effects of repeated treatment with an extract of Ginkgo biloba (EGb 761), Bilobalide and Ginkgolide B on the electrical activity of pancreatic ß cells of normal and alloxan-diabetic mice : an ex vivo study with intracellular microelectrodes |
| Vasseur M., Jean T., Defeudis F., and Drieu K. (1994) |
| Gen. Pharmacol. , 25: 31-46 |
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| Etude in vitro de l'effet anti-inflammatoire de la diosmine d'hémisynthèse dans un système de co-culture de cellules endothéliales veineuses et de granulocytes humains |
| Bodinier M.C., Ly S.M., Finet M. and Jean T. (1994) |
| Artères et veines , 13: 124-128 |
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| Mediators involved in inflammation: effects of Daflon 500 mg on their release. |
| Jean T. and Bodinier M.C. (1994) |
| Angiology, 45: 554-559 |
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| Up-regulation of [3H]-des-Arg10-kallidin binding to the bradykinin B1 receptor by interleukin-1ß in isolated smooth muscle cells: correlation with B1 agonist-induced PGI2 production |
| Galizzi J.P., Bodinier M.C., Chapelain B., Ly S.M., Coussy L., Giraud S., Néliat G. and Jean T. (1994) |
| Br. J. Pharmacol. , 113: 389-394 |
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| Different effects of interleukin-1 on reactivity of arterial vessels isolated from various vascular beds in the rabbit |
| Robert R., Chapelain B. and Neliat G. (1993) |
| Circ. Shock, 40: 139-143 |
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| In vitro and in vivo biological activities of SR 140333, a novel potent non-peptide tachykinin NK1 receptor antagonist. |
| Emonds-Alt X., Doutremepuich J.D., Heaulme M., Neliat G., Santucci V., Steinberg R., Vilain P., Bichon D., Ducoux J.P., Proietto V., Van Broeck D., Soubrié P., Le Fur G. and Brelière J.C (1993) |
| Eur. J. Pharmacol., 250: 403 |
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| Peripheral biological activity of SR 27897 : a new potent non-peptide antagonist of CCKA receptors |
| Gully D., Frehel D., Marcy C., Spinazze A., Lespy L., Neliat G., Maffrand J. P. and Le Fur G. (1993) |
| Eur. J .Pharmacol. , 232: 13-19 |
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| SR 48968, a neurokinin A (NK2) receptor antagonist |
| Emonds-Alt X., Advenier C., Croci T., Manara L., Neliat G., Poncelet M., Proietto V., Santucci V., Soubrié P., Van Broeck D., Vilain P., Le Fur G., and Brelière J. C. (1993) |
| Reg. Peptides, 43: 31-36 |
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| Study of anthiatherogenic properties of indapamide in a pharmacologic model |
| Lebrillant E., Roulet M. J., Robert R., Schiavi P., Guez D., and Jean T. (1993) |
| J. Cardiovasc. Pharmacol., 22: (sup. 6) S53-S56 |
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| A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. |
| Emonds-Alt X., Vilain P., Goulaouic P., Proietto, V., Van Broeck D., Advenier C., Naline E., Neliat G., Le Fur G. and Brelière J.C. (1992) |
| Life Sci. (1992), 50: PL101-PL106 |
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| Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist |
| Rinaldi-Carmona M., Congy C., Santucci V.,Simiand J., Neliat G., Labeeuw G., Le Fur G., Soubrié P. and Brelière J. C. (1992) |
| J. Pharmacol. Exp. Ther. , 262: 759-768 |
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| Interleukin-1 impairs both vascular contraction and relaxation in rabbit isolated aorta. |
| Robert R., Chapelain B., Jean T., and Neliat G. |
| Biochem. Biophys. Res. Commun., (1992), 182: 733-739 |
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| Neurokinin A (NK2) receptor revisited with SR 48968, a potent non-peptide antagonist. |
| Advenier C., Rouissi N., Nguyen Q. T., Emonds-Alt X., Brelière J.C., Neliat G., Naline E., and Regoli D. (1992) |
| Biochem. Biophys. Res. Commun. , 184: 1418-1424 |
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| Characterization of ß-adrenoceptor subtypes and indications for two cell populations in isolated bovine mesenteric lymphatic vessels. |
| Mahé L., Chapelain B., Gargouil Y. M., and Neliat G. (1991) |
| Eur. J. Pharmacol., 199: 19-25 |
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| Role of the epithelium in the action of fenspiride on the isolated guinea-pig and rat trachea. |
| Chapelain B., Neliat G., Bodinier M. C., Jean T., Evrard Y., and Gargouil Y. M. |
| Eur. Respir. Rev., (1991), 2: 86-92 |
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