Form
Dry powder, or
10 mM DMSO stock solution.

For any other form please inquire.
For frozen samples, please allow for enough dry ice to arrive frozen at Cerep site.
In addition, it is very important to show on documents and mark on package that compound(s) must be kept in dry ice during all the shipment (from its collection to its delivery at the Cerep site).

Format
securely closed vials, or
individual 2D barecode tubes, or
sealed 96-well plates (all SBS format standard plates are accepted): columns 1 and 12 empty and test compounds placed in A2-H11 column-wise), or
sealed 384-well plates (all SBS format standard plates are accepted): columns 1, 2, 23 and 24 empty and test compounds placed in A3-P22 column-wise).

For any other format please inquire.

To reduce the registration time and ensure that all the appropriate information is available to start the study in a shortest possible timeframe, please use Cerep compound submission form.

You can also send your own MS Excel file ⁽¹⁾ providing the following compound information:
Name (compound ID) / Batch # / Molecular weight ⁽²⁾/ Formula weight ⁽³⁾/ Stock concentration / Stock solvent / Quantity / Unit ⁽⁴⁾ / Form / Storage conditions / Solubility, as well as Plate ID / plate position for compounds delivered in plates, Comments ⁽⁵⁾, and Quotation number.

NOTE: Impurity and colored compounds might affect the results (compound color information is mentioned in the study report).

⁽¹⁾ Systematically required for studies of 10 compounds or more.
⁽²⁾ Molecular weight (MW) of free acid or base form.
⁽³⁾ Formula weight (FW) including salt form and/or hydrate form if applicable.
⁽⁴⁾ mg?, mL?
⁽⁵⁾ e.g. useful information such as sensitivity to light, stability or hygroscopicity issues.

 Binding, enzyme and cellular assays
Assuming a molecular weight < 500 g/mol and a testing concentration of 10 µM in duplicate (including a possible retest).



 Tissue assays
For screening at 3 concentrations in duplicate (2 tissues) or follow-up: sufficient amount to prepare 150 µL of a 1000-fold concentrated solution relative to the highest test concentration for each assay.
Maximum tolerable final DMSO concentration: 0.1%.

 ADME-Tox assays
Assuming a molecular weight < 500 g/mol and assays tested at default concentrations (including retest).



 Minimum compound amount for standard profiles
For screening and follow-up with highest concentration at 10µM and 100 µM, please click here.

 Requested compound information

 To reduce the registration time and ensure that all the appropriate information is available to start the study in a shortest possible timeframe, please use Cerep compound submission form ⁽¹⁾ or MS Excel file ⁽²⁾, and provide the following compound information:

Name (compound ID) / Batch # / Molecular weight ⁽³⁾/ Formula weight ⁽⁴⁾ / Stock concentration / Stock solvent / Quantity / Unit ⁽⁵⁾ / Form / Storage conditions / Solubility, as well as Plate ID / plate position for compounds delivered in plates, Comments ⁽⁶⁾, and Quotation number.

Note: Impurity and colored compounds might affect the results (compound color information is mentioned in the study report).

¹ Cerep compound submission form will be emailed to you with your quotation. A copy can be requested from sales@cerep.com, or downloaded, please click here
² Systematically required for studies of 10 compounds or more.
³ Molecular weight (MW) of free acid or base form.
⁴ weight (FW) including salt form and/or hydrate form if applicable.
⁵ mg?, mL?
⁶ e.g. useful information such as sensitivity to light, stability or hygroscopicity issues.


 General remarks:
 If compound(s) are supplied as a stock solution in plate(s) (preferred format for any submission of 10 or more compounds), please leave columns 1 and 12 empty in a 96W plate. The 384W plate format is also acceptable with columns 1, 2, 23 and 24 empty. For any other plate format, please inquire.

 If compound(s) are not soluble in 100% DMSO, please provide any useful information concerning the solubility of the compound. The following solvents are compatible with most of our assays: DMSO (Cerep standard), H₂O, Methanol, Tris/HCl 10mM pH 7.4

 Organic solvents such as acetone, chloroform, ether, acetonitrile (Except for CYP assays), tetrahydrofuran and trifluoroacetic acid are not recommended as they will significantly affect the results from many in vitro assays, even at very low concentrations.


 Remarks for ADME-Tox assays:
 Any study including mass spectrometry (MS) assays (such as stability, permeability, protein binding) requires both molecular weight (MW) and formula weight (FW) of each tested compound, even if they are the same. The FW is required to prepare the stock solution of each compound at the correct concentration. The MW gives indication on which expected molecular ion to look for in our LC-MS screen assay.
 Chemical structure is required for Metabolite characterization.
 Chemical structure or list of the ionizable groups is required for pKa.
 Solubility information is useful and recommended for pKa and genotoxicity testing (due to high test concentrations).

Compounds can be shipped¹ at any of the two sites below (Cerep will manage the compound transfer to the other testing site when necessary):

 Cerep
Attn: Compound receipt manager
Le Bois l’Evêque
86600 Celle l’Evescault
FRANCE
Tel. +33 (0)5 49 89 30 00

 Cerep
Attn: Compound receipt manager
15318 NE 95th St
Redmond, WA 98052
USA
Tel. +1 (425) 895 8666

Every shipment of compounds going through customs must include a commercial invoice.
For shipments going through US customs: a TSCA form (Toxic Substance Control Act) is required (templates are available upon request).

For customers located in China, compounds can be shipped to :
 Cerep
Ai Di Sheng (Edison) Road 326, 302-1 room
Zhangjiang Hich-Tech Park
Shanghai - CHINA
Tel. +86 187 021 60370


To assist Cerep in efficiently processing compounds upon receipt, the following information is helpful to ensure the appropriate follow-up of shipment and streamlined initiation of the testing:
 Advance notice of shipment to Cerep – e-mail : compoundreceipt@cerep.com
 Shipment tracking number

¹ Preferred carriers: FedEx for room temperature and World Courrier for dry ice shipment.